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Many active drug compounds share the same problem: low solubility and rapid elimination from the body before they can deliver a therapeutic effect. In one study, syringic acid encapsulated in MIL-100(Fe) reached a drug loading of 64.42% in just 12 hours, and when tested in a rat model, its bioavailability increased almost 11-fold compared to plain oral administration. That result was made possible by MIL-100(Fe)'s giant mesoporous cages, measuring 25 and 29 angstroms across, among the largest...

Most MOFs remain stuck at the laboratory scale, difficult to produce beyond a few grams at a time. Al-Fum is the exception. Known commercially as Basolite A520, it's one of the first MOFs BASF successfully manufactured at ton scale through a fully solvent-free, water-based synthesis, reaching a space-time yield of 3,600 kilograms per cubic meter per day, a breakthrough that even won the Pierre Potier Prize for sustainable chemistry innovation. Al-Fum (Aluminum Fumarate) is an aluminum-based...

Most CO₂-capturing MOFs share the same weakness: their performance collapses the moment water vapor is present, and real-world industrial flue gas is almost always humid. MIL-96(Al) does the opposite. Research testing this material at relative humidity levels up to 40% found that at a moderate 10% RH, its affinity for CO₂ actually increases, because water and CO₂ fill different pore cavities within its structure rather than competing for the same space. MIL-96(Al) is an aluminum-based MOF...